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Product trade name: Ambral
Pharmaceutical active ingredients containing related brand and generic drugs, medications or other health care products: Ambral available forms, composition, doses: Ambral destination | category: Indications and usages, anatomical therapeutic chemical and diseases classification codes: Pharmaceutical companies, researchers, developers, manufacturers, distributors and suppliers: Online pharmacy, drugstores, pharma, health and beauty shops selling this or related pharmaceutical products: There is an additional general information about this medication active ingredient metronidazole: Pharmacological action Ambral is an anti protozoal agent. It is believed that the mechanism of action is associated with DNA damage-sensitive microorganisms. Active against Trichomonas vaginalis, Gardnerella vaginalis, Giardia lamblia, Entamoeba histolytica, and obligate anaerobic bacteria (including Bacteroides spp., Fusobacterium spp.). Aerobic bacteria are resistant to metronidazole. In combination with amoxicillin Ambral is active against Helicobacter pylori. It is believed that amoxicillin inhibits the development of resistance of Helicobacter pylori to metronidazole. Pharmacokinetics Ambral well absorbed after oral administration. The bioavailability is 80%. Metronidazole is distributed in tissues and body fluids. This medication crosses the placental barrier and the BBB. Binding to plasma proteins is 20%. Metronidazole is metabolized in the liver by oxidation and binding to glucuronic acid. T1/2 is 8 hours. This drug is excreted in the urine (60-80%) and feces (6-15%). Why is Ambral prescribed? Trichomonazice vaginitis and urethritis in women, trichomonazice urethritis in men, giardiasis, amoebic dysentery, anaerobic infections caused by metronidazole-sensitive organisms, combination therapy of severe mixed aerobic-anaerobic infections. Preventing anaerobic infection in surgery (particularly abdominal, urinary tract). Chronic alcoholism. Ambral in combination with amoxicillin: chronic gastritis in acute phase, gastric ulcer and duodenal ulcer in acute phase, associated with Helicobacter pylori. For external and topical use: treatment of acne vulgaris and pink, bacterial vaginosis, treatment of long-term healing of wounds and trophic ulcers. Dosage and administration Ambral is administered for oral use for adults and children over 12 years in 7.5 mg / kg every 6 h or 250-750 mg 3-4 times / day. For children up to 12 years the dose is 5-16.7 mg / kg 3 times / day. For IV injections for adults and children over 12 years starting dose is 15 mg / kg, followed by 7.5 mg / kg every 6 hours or depending on the etiology of the disease - by 500-750 mg every 8 hours. The duration of treatment and frequency of tests is determined individually. Intravaginally - 500 mg 1 time a night. In combination with amoxicillin (2.25 g / day) daily dose of metronidazole is 1.5 g; multiplicity of admission - 3 times / day. For patients with severe renal impairment (creatinine clearance less than 30 ml / min) and / or liver daily dose of metronidazole is 1 g (amoxicillin - 1.5 g / day), the multiplicity of the reception is 2 times / day. This medication takes for external and local use 2 times / day, doses are determined individually. The maximum daily dose for adults when taken orally and IV is 4 g. Ambral side effects, adverse reactions Digestive system: nausea, vomiting, anorexia, metallic taste in the mouth. CNS and peripheral nervous system: headache, nervousness, irritability, insomnia, dizziness, ataxia, weakness, confusion, depression, peripheral neuropathy, seizures, hallucinations. Allergic reactions: skin rash, itching, hives. Hemopoietic system: leucopenia. Local reactions: irritation. Other: arthralgia, burning sensation in the urethra. Ambral contraindications Organic CNS lesions, blood diseases, liver problems, I trimester of pregnancy, hypersensitivity to metronidazole. Using during pregnancy and breastfeeding Metronidazole is rapidly crosses the placental barrier. In II and III trimester of pregnancy Ambral is used only for health reasons. Metronidazole is excreted in breast milk. If necessary, use during lactation should solve the issue of termination of breastfeeding. Special instructions Patients should with careful use of Ambral in liver diseases. In combination with amoxicillin this medication is not recommended for patients younger than 18 years. During the treatment period it is necessary the regular control of pattern of peripheral blood. During the treatment of Trichomonas vaginitis in women and Trichomonas urethritis in men patients should refrain from sexual activity, simultaneous treatment of both partners is mandatory. During the taking of metronidazole there is a more dark staining of urine. During treatment with metronidazole should avoid alcohol because to violations of the oxidation of alcohol can accumulate acetaldehyde. As a result may develop reactions similar to those characteristic of disulfiram (abdominal cramps, nausea, vomiting, headache, a sudden rush of blood to the face). Ambral drug interactions Simultaneous administration of Ambral with: Ambral in case of emergency / overdose Symptoms: nausea, vomiting, ataxia, in severe cases - peripheral neuropathy and seizures. Treatment: symptomatic, there is no specific antidote.
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