|
||||
|
Product trade name: Cardifen
Pharmaceutical active ingredients containing related brand and generic drugs, medications or other health care products: Cardifen available forms, composition, doses: Cardifen destination | category: Indications and usages, anatomical therapeutic chemical and diseases classification codes: Pharmaceutical companies, researchers, developers, manufacturers, distributors and suppliers: Online pharmacy, drugstores, pharma, health and beauty shops selling this or related pharmaceutical products: There is an additional general information about this medication active ingredient nifedipine: Pharmacological action Cardifen is aSelective calcium channel blocker class II, a derivative of dihydropyridine. This medication inhibits the entry of calcium into cardiomyocytes and vascular smooth muscle cells. Nifedipine has antianginal and hypotensive action. This drug lowers the tone of vascular smooth muscle. Cardifen dilates coronary and peripheral arteries, lowers blood pressure and slightly - myocardial contractility, reduces afterload and myocardial oxygen demand. This medicine improves coronary blood flow. Nifedipine practically does not possess antiarrhythmic activity, it does not inhibit the conductance of myocardium. Pharmacokinetics When administered orally Cardifen is rapidly absorbed from the gastrointestinal tract. This drug undergoes metabolism in the "first pass" through the liver. The protein binding is 92-98%. Nifedipine metabolized in the liver to form inactive metabolites. T1/2 is about 2 hours. This medication excreted mainly by the kidneys as metabolites in trace amounts in unchanged form; 20% is excreted from the gut in the form of metabolites. Why is Cardifen prescribed? Prevention of angina attacks (including vasospastic angina), in some cases - relief of angina attacks, hypertension, hypertensive crises, Raynaud's disease. Dosage and administration The dosing regimen is individual. For oral administration the initial dose is 10 mg 3-4 times / day. If necessary the dose gradually increased up to 20 mg 3-4 times / day. In some cases (variant angina, severe hypertension) for a short time the dose can be increased to 30 mg 3-4 times / day. For relief of hypertensive crisis, as well as angina attack this drug can be used sublingually in 10-20 mg (rarely 30 mg). To IN relieve an angina attack or hypertensive crisis - 5 mg for 4-8 hours. Intracoronary dose for relief of acute coronary artery spasm injected bolus is 100-200 mcg. With stenosis of major coronary vessels starting dose is 50-100 micrograms. The maximum daily dose: oral - 120 mg, IV - 30 mg. Cardifen side effects, adverse reactions Cardiovascular: flushing of the skin, a feeling of warmth, tachycardia, hypotension, peripheral edema; rarely - bradycardia, ventricular tachycardia, asystole, increased angina attacks. Digestive system: nausea, heartburn, diarrhea, rarely - liver function impairment and in rare cases - gingival hyperplasia. The chronic administration in high doses may cause dyspeptic symptoms, elevated liver enzymes, intrahepatic cholestasis. CNS and peripheral nervous system: headache. The chronic administration in high doses may cause paresthesia, muscle pain, tremors, visual disturbances light, and sleep disorders. Hemopoietic system: in rare cases - leukopenia, thrombocytopenia. Urinary system: an increase in daily diuresis. The chronic administration in high doses may cause renal dysfunction. Endocrine system: in rare cases - gynecomastia. Allergic reactions: skin rash. Local reactions: for IV injections might burning at the injection site. Within 1 min after intracoronary administration it can be a result in the negative inotropic action of nifedipine, the increase in heart rate, hypotension, and these symptoms gradually disappear within 5-15 minutes. Cardifen contraindications Hypotension (systolic blood pressure below 90 mm Hg), collapse, cardiogenic shock, severe heart failure, severe aortic stenosis; increased sensitivity to nifedipine. Using during pregnancy and breastfeeding Adequate and well-controlled studies safety of nifedipine in pregnancy was not been conducted. The use of Cardifen in pregnancy is not recommended. Because nifedipine is excreted in breast milk, you should avoid its use during lactation or to stop breastfeeding during the treatment with this medication. In experimental studies it have been revealed embryotoxic, fetotoxic and teratogenic effects of nifedipine. Category effects on the fetus by FDA - C. Special instructions In patients with stable angina at the beginning of treatment paradoxical enhancement anginalnyh pain may occurs, with pronounced coronary sclerosis and unstable angina - the aggravation of myocardial ischemia. Not recommended to use short-acting drugs for long-term treatment of angina or hypertension, because it is possible the development of unpredictable changes in BP and reflex angina. Cardifen drug interactions Nitrates, beta-blockers, diuretics, tricyclic antidepressants, fentanyl, alcohol increase the hypotensive effect of Cardifen. This medication increases the activity of theophylline reduces the renal clearance of digoxin. Nifedipine increases the side effects of vincristine (reduced elimination); increases the bioavailability of cephalosporins (cefixime). Cimetidine and ranitidine increase the level of this drug in plasma. Diltiazem slows the metabolism (requires dose reduction of nifedipine) of Cardifen. This medicine is incompatible with rifampicin (accelerates biotransformation and does not allow to create effective concentration). Grapefruit juice (large quantity) increases its bioavailability. Cardifen in case of emergency / overdose Symptoms: sudden bradycardia, bradyarrhythmia, hypotension, in severe cases - collapse, slowing conduction. When you receive a large number of retard-tablets symptoms of intoxication occur no earlier than 3-4 h and may additionally be expressed in loss of consciousness up to coma, cardiogenic shock, convulsions, hyperglycemia, metabolic acidosis, hypoxia. Treatment: gastric lavage, activated charcoal method, injections of norepinephrine, calcium chloride or calcium gluconate in a solution of atropine (IV). Hemodialysis is ineffective.
Comments
Vanessa Coetzee 12 Nov 2007, 00:43
I went into premature labour at 35w 3d and was given Cardifen Capsules
10mg, two every 15 minutes for an hour. The contractions stopped, but
started again about a day later and I was given another two tablets about
half an hour apart. I had a C-section about three hours after as the
contractions didn't stop. My baby was born with severe brain damage and
died six days later. I suspect it was the medicine as there is no other
logical explanation.
katrina 12 Oct 2010, 03:20
Just want to know about the safety of the medicine i am 30 weeks pregnant
and was put on this drug to stop contraction and premature labour .
Wilms 15 Aug 2011, 00:53
Halo I'm 32wks pregnant and have been in and out of hospital with pre term
labour. The last time dr gave me cardifen 10mg tablets and after a while my
baby is very active and her heartrate stays above 185-199. Is she in any
danger?I have to take these tablets 6 hourly, I'm really scared and worried
about her. The tablets make me nasaus and its hard to breath. Please be
quick to advise me about this. Regards Wilma
ula 21 Aug 2011, 13:22
Hi, i just got the stitch in 14 weeks pregnancy and efter that dr gave me
those tablets one per day. is it safe for my baby to use them or should i
rather give up on them? i think magnesium is better to take for the
contractions and its safe. what is happening to the baby after i take those
tablets?
Japie Botha 26 Jan 2012, 19:51
Hi, I am a sixty three year old male. I was diagnosed with a problem in
swallowing food or drinks as this used to block in my throat. After a
Barium meal they found out tht my tube to my stomach had a corkscrew
effect. The doctor prescribed 2x5Mg Cardifem to overcome this problem. I am
still on trial - will this help?? Any one out there?
|
|
|||
|
||||