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Product trade name: Celin
Pharmaceutical active ingredients containing related brand and generic drugs, medications or other health care products: Celin available forms, composition, doses: Celin destination | category: Indications and usages, anatomical therapeutic chemical and diseases classification codes: Pharmaceutical companies, researchers, developers, manufacturers, distributors and suppliers: Online pharmacy, drugstores, pharma, health and beauty shops selling this or related pharmaceutical products: There is an additional general information about this medication active ingredient vitamin c (ascorbic acid): Pharmacological action Ascorbic acid (vitamin c) is essential for the formation of intracellular collagen, is required to strengthen the structure of teeth, bones, and the capillary walls. Celin participates in redox reactions, the metabolism of tyrosine, converting folic acid into folinic acid, metabolism of carbohydrates, the synthesis of lipids and proteins, iron metabolism, processes of cellular respiration. Reduces the need for vitamins B1, B2, A, E, folic acid, pantothenic acid, enhances the body's resistance to infections; enhances iron absorption, contributing to its sequestration in reduced form. Celin has antioxidant properties. With intravaginal application of ascorbic acid lowers the vaginal pH, inhibiting the growth of bacteria and helps to restore and maintain normal pH and vaginal flora (Lactobacillus acidophilus, Lactobacillus gasseri). Pharmacokinetics After oral administration ascorbic acid is completely absorbed from the gastrointestinal tract. Widely distributed in body tissues. The concentration of ascorbic acid in blood plasma in normal amounts to approximately 10-20 mg / ml. The concentration of ascorbic acid in white blood cells and platelets is higher than in erythrocytes and plasma. When deficient state of concentration in leucocytes is reduced later and more slowly and is regarded as the best criterion for evaluating the deficit than the concentration in plasma. Plasma protein binding is about 25%. Ascorbic acid is reversibly oxidized to form dehydroascorbic acid, is metabolized with the formation of ascorbate-2-sulphate which is inactive and oxalic acid which is excreted in the urine. Ascorbic acid taken in excessive quantities is rapidly excreted unchanged in urine, it usually happens when exceeding a daily dose is 200 mg. Why is Celin prescribed? For systemic use of Celin: prevention and treatment of hypo- and avitaminosis of vitamin C; providing increased need for vitamin C during growth, pregnancy, lactation, with heavy loads, fatigue and during recovery after prolonged severe illness; in winter with an increased risk of infectious diseases. For intravaginal use: chronic or recurrent vaginitis (bacterial vaginosis, nonspecific vaginitis) caused by the anaerobic flora (due to changes in pH of the vagina) in order to normalize disturbed vaginal microflora. Dosage and administration This medication administered orally, IM, IV, intravaginally. For the prevention of deficiency conditions Celin dose is 25-75 mg / day, for the treatment - 250 mg / day or more in divided doses. For intravaginal used ascorbic acid drugs in appropriate dosage forms. Celin side effects, adverse reactions CNS: headache, fatigue, insomnia. Digestive system: stomach cramps, nausea and vomiting. Allergic reaction: describes a few cases of skin reactions and manifestations of the respiratory system. Urinary system: when used in high doses - hyperoxaluria and the formation of kidney stones of calcium oxalate. Local reactions: with intravaginal application - a burning or itching in the vagina, increased mucous discharge, redness, swelling of the vulva. Other: sensation of heat. Celin contraindications Increased sensitivity to ascorbic acid. Using during pregnancy and breastfeeding The minimum daily requirement of ascorbic acid in the II and III trimester of pregnancy is about 60 mg. Ascorbic acid crosses the placental barrier. It should be borne in mind that the fetus can adapt to high doses of ascorbic acid, which takes a pregnant woman, and then a newborn baby may develop the ascorbic disease as the reaction of cancel. Therefore, during pregnancy should not to take ascorbic acid in high doses, except in cases where the expected benefit outweighs the potential risk. The minimum daily requirement during lactation (breastfeeding) is 80 mg. Ascorbic acid is excreted in breast milk. A mother's diet that contains adequate amounts of ascorbic acid, is sufficient to prevent deficiency in an infant. It is unknown whether dangerous to the child's mother use of ascorbic acid in high doses. Theoretically it is possible. Therefore, it is recommended not to exceed the maximum daily nursing mother needs to ascorbic acid, except when the expected benefit outweighs the potential risk. Special instructions Celin is used with caution in patients with hyperoxaluria, renal impairment, a history of instructions on urolithiasis. Because ascorbic acid increases iron absorption, its use in high doses can be dangerous in patients with hemochromatosis, thalassemia, polycythemia, leukemia, and sideroblastic anemia. Patients with high content body iron should apply ascorbic acid in minimal doses. Celin is used with caution in patients with deficiency of glucose-6-phosphate dehydrogenase. The use of ascorbic acid in high doses can cause exacerbation of sickle cell anemia. Data on the diabetogenic action of ascorbic acid are contradictory. However, prolonged use of ascorbic acid should periodically monitor your blood glucose levels. It is believed that the use of ascorbic acid in patients with rapidly proliferating and widely disseminated tumors may worsen during the process. It should therefore be used with caution in ascorbic acid in patients with advanced cancer. Absorption of ascorbic acid decreased while use of fresh fruit or vegetable juices, alkaline drinking. Celin drug interactions In an application with barbiturates, primidone increases the excretion of ascorbic acid in the urine. With the simultaneous use of oral contraceptives reduces the concentration of ascorbic acid in blood plasma. In an application of Celin with iron preparations ascorbic acid, due to its regenerative properties, transforms ferric iron in the bivalent, which improves its absorption. Ascorbic acid in high doses can decrease urine pH that while the application reduces the tubular reabsorption of amphetamine and tricyclic antidepressants. With the simultaneous use of aspirin reduces the absorption of ascorbic acid by about a third. Celin in an application with warfarin may decrease effects of warfarin. With the simultaneous application of ascorbic acid increases the excretion of iron in patients receiving deferoxamine. In the application of ascorbic acid at a dose of 500 mg / day possibly left ventricular dysfunction. In an application with tetracycline is increased excretion of ascorbic acid in the urine. There is a described case of reducing the concentration of fluphenazine in plasma in patients treated with ascorbic acid 500 mg 2 times / day. May increase the concentration of ethinyl estradiol in the blood plasma in its simultaneous application in the oral contraceptives. Celin in case of emergency / overdose Symptoms: long-term use of large doses (more than 1 g) - headache, increased CNS excitability, insomnia, nausea, vomiting, diarrhea, gastritis giperatsidnyh, ultseratsiya gastrointestinal mucosa, inhibition of the function insular apparatus of the pancreas (hyperglycemia, glycosuria), hyperoxaluria, nephrolithiasis (calcium oxalate), damage to the glomerular apparatus of the kidneys, moderate thamuria (when receiving a dose of 600 mg / day). Decrease capillary permeability (possibly deteriorating trophic tissues, increased blood pressure, hypercoagulability, the development of microangiopathy). When IV administration in high doses - the threat of termination of pregnancy (due to estrogenemia), hemolysis of red blood cells.
Comments
rahul 27 Jun 2010, 05:38
in wich purpose in this tablets use?
shiva 09 Dec 2010, 07:58
i am using the celin for more than eight months there is a possibilty of
any side effects
jene 28 Dec 2010, 02:05
my son is using celin for 2 years he is 4 yrs old now. we are not measuring
in cup anymore because we know the approx dosage but i think its not exact.
and yesterday he drank about 1000mg of it. does it have side effect?he
likes celin taste so i'm worried he drinks it if nobody see him
soumya 27 Jan 2011, 15:20
Is Celin will be helpful in cold, such as sneezing or watering from nose?
bk 04 Feb 2011, 11:41
Is Celin helpful in cold, such as sneezing or watering from nose?
Gautam singh 25 Jun 2011, 01:59
I m taking celin from 1 week nd i notice that some allergic reaction on my
face, wht is this?
Sankalp 28 Jun 2011, 12:34
ya i also noticed some allergic reaction on my face,is it from celin,plz
inform
Zim 03 Nov 2011, 16:36
I just take one or two celin when I have colds...and it really helps me get
rid of the sneezing and watering of the nose!! I am not a regular user
though!!
D Bagchi 15 Jan 2012, 20:58
i'm also suffering from severe allergic reactions on my face due to celin.
Anand 06 Feb 2012, 12:02
Celin may not be very useful once cold and runny nose has started as it
takes time to act. Moreover the extra intake will only be wasted in the
urine. To restrict the onset of common cold and runny noses, you need to
take a regular dosage of Vitamin C. Like 2 to 3 tablets in a week at
equally spaced intervals during the cold season. This will keep it under
balance and improve your immunity. But remember, you must get yourself
checked for conditions that can get aggravated with Vit. C before you
start. A safe way is to take one Celin tablet each week.
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