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Product trade name: Clonazepam
Pharmaceutical active ingredients containing related brand and generic drugs, medications or other health care products: Clonazepam available forms, composition, doses: Clonazepam destination | category: Indications and usages, anatomical therapeutic chemical and diseases classification codes: Pharmaceutical companies, researchers, developers, manufacturers, distributors and suppliers: Online pharmacy, drugstores, pharma, health and beauty shops selling this or related pharmaceutical products: There is an additional general information about this medication active ingredient clonazepam: Pharmacological action Clonazepam Mylan Pharmaceuticals is an antiepileptic drugs from the group of benzodiazepine derivatives. This medication has a pronounced anticonvulsant and central muscle relaxant, anxiolytic, sedative and hypnotic effects. Clonazepam strengthens the inhibitory effect of GABA on the transmission of nerve impulses. Anxiolytic effects of this drug is due to the influence on the amygdaloid complex of the limbic system and appears in reducing the emotional stress, reduce anxiety, fear, anxiety. The sedation effects is due to the influence on the reticular formation of the brainstem and nonspecific thalamic nucleus and manifests a decrease in neurotic symptoms (anxiety, fear). Anticonvulsant effect is realized by increasing presynaptic inhibition. The central muscle relaxant effect is due to inhibition of spinal polysynaptic afferent inhibitory ways (to a lesser extent and monosynaptic). It is possibly and direct inhibition of motor nerves and muscle function. Pharmacokinetics For oral administration of Clonazepam Mylan Pharmaceuticals its bioavailability is more than 90%. The plasma protein binding is more than 80%. Vd is 3.2 L / kg. T1/2 is 23 hours. This drug is excreted mainly as metabolites. Why is Clonazepam Mylan Pharmaceuticals prescribed? As the medication of I row - epilepsy (adults, infants and young children): typical absence seizures (petit mal), atypical absence seizures (Lennox-Gastaut syndrome), nodding spasm, atonic seizures (a syndrome of "falling" or "drop-attacks"). As the medication of II row - infantile spasms (West syndrome). As the medication of III row - tonic-clonic seizures (grand mal), simple and complex partial seizures and secondary generalized tonic-clonic seizures. Status epilepticus (IV injections). Somnambulism, muscular hypertonicity, insomnia (especially in patients with organic brain damage), psychomotor agitation, alcohol withdrawal syndrome (acute agitation, tremor, threatening or acute delirium tremens and hallucinations), panic disorder. Dosage and administration Dosing regimen of Clonazepam Mylan Pharmaceuticals is individual. For oral administration for adults the recommended initial dose is not more than 1 mg / day. The maintenance dose is 4-8 mg / day. For infants and children aged 1-5 years, the initial dose should not exceed 250 micrograms / day, for children aged 5-12 years - 500 mcg / day. Supporting daily doses for children under 1 year are 0.5-1 mg, 1-5 years - 1-3 mg, 5-12 years - 3-6 mg. For elderly patients the recommended starting dose is not exceeding 500 micrograms. The daily dose should be divided into 3-4 equal doses. Maintenance doses prescribed in 2-3 weeks of treatment. IV (slowly) for adults - 1 mg, for children under the age of 12 years - 500 mcg. Clonazepam Mylan Pharmaceuticals side effects, adverse reactions CNS: early treatment - severe lethargy, fatigue, drowsiness, weakness, dizziness, stupor, headache; rarely - confusion, ataxia. When used in high doses, especially in long-term treatment - violation of articulation, diplopia, nystagmus, paradoxical reactions (including acute excitation states); anterograde amnesia. Rarely - hyperergic reactions, muscle weakness - depression. With long-term treatment of some forms of epilepsy may increase the frequency of seizures. Digestive system: rarely - dry mouth, nausea, diarrhea, heartburn, nausea, vomiting, decreased appetite, constipation or diarrhea, liver damage, elevated liver transaminases and alkaline phosphatase, jaundice. In infants and young children may increase salivation. Cardiovascular system: decreased blood pressure, tachycardia. Endocrine: changes in libido, dysmenorrhea, reversible premature sexual development in children (part-time early puberty). Respiratory system: with / in the introduction possible respiratory depression, particularly after treatment with other medicines that cause respiratory depression; in infants and young children it is possible bronchial hypersecretion. Hematopoietic system: leukopenia, neutropenia, agranulocytosis, anemia, and thrombocytopenia. Urinary system: urinary incontinence, urinary retention, impaired renal function. Allergic reactions: hives, skin rash, itching, extremely rare - anaphylactic shock. Dermatological reactions: transient alopecia, discoloration. Other: addiction, drug dependence, with a sharp decrease in dose or cessation of reception - a withdrawal syndrome. Clonazepam Mylan Pharmaceuticals contraindications Inhibition of the respiratory center, severe COPD (the progression of the degree of respiratory failure), acute respiratory failure, myasthenia gravis, coma, shock, angle-closure glaucoma (acute attack or predisposition), acute alcohol intoxication with the weakening of the vital functions, acute poisoning with narcotic analgesics and hypnotics, severe depression (suicidal tendencies may occur), pregnancy, lactation, hypersensitivity to clonazepam. Using during pregnancy and breastfeeding Clonazepam Mylan Pharmaceuticals is contraindicated for use during pregnancy and lactation. This medication crosses the placental barrier. Clonazepam may be excreted in breast milk. Category effects on the fetus by FDA - D. Special instructions With caution used in patients with ataxia, severe liver disease, severe chronic respiratory failure, especially in the acute stage of deterioration, with episodes of sleep apnea. With careful use in elderly patients because they may be slowed by removal of clonazepam and reduced tolerance, especially in the presence of cardio-pulmonary insufficiency. With prolonged use of this drug it may develop drug dependence. With a sharp lifting of clonazepam after long-term treatment it may been developed the withdrawal syndrome. In long-term use of Clonazepam Mylan Pharmaceuticals in children should be kept in mind the possibility of side effects on physical and mental development, which may not manifest for years. During the period of treatment avoid to drink alcohol. During the period of treatment is observed slowing of psychomotor responses. It is necessary to take into account persons engaged in potentially hazardous activities that require attention and quickness of psychomotor reactions. Clonazepam Mylan Pharmaceuticals drug interactions Simultaneous administration of Clonazepam Mylan Pharmaceuticals with: Clonazepam Mylan Pharmaceuticals in case of emergency / overdose Symptoms: CNS depression of varying severity (from lethargy to coma): severe drowsiness, prolonged confusion, depression of reflexes, coma, possible respiratory depression. Treatment: induction of vomiting and the prescription of activated charcoal (if the patient is conscious), gastric lavage through a tube (if patient is unconscious), symptomatic therapy, monitoring of vital functions (breathing, pulse, blood pressure), in intravenous fluids (to increase urine output), if necessary, mechanical ventilation. As a specific antidote may be used benzodiazepine receptor antagonist flumazenil (in hospital), however, flumazenil is not indicated for use in patients with epilepsy (likely provocation of epileptic seizures).
Comments
otonielcolon 25 Jun 2011, 13:54
my name isa mr colon i for many times have fill a prescription at cvs and
they only carrie klonopin made by mylan and they suck i usually go to
walgreens and they have the klonopin carrid by puepec labs, this klonopin
really are the by all means the the lowes in the inventory. i just got back
fron afganistanand i need this mediction for my ptsd. i had to pay for a
mediction that does not meed the standers that i wsa hoping for. i will be
very cofterbele if i can have the a rtefund off a other brad please under
stand i nedd this medication becuase of my expiriance in combat one more
time i pay for this brand of klonopin and its fore give my exprcion but its
no good at all sincerlly usmarine sgt colon my emial is
otonielcolon@yahoo.com
otoniel colon 18 Sep 2011, 21:26
For 5 yrars i have been taking generic klonopin with is clonozopm .My
problem is that i can only take only one type of clonozopm. Maylan sandof
teva .One famaly member told me to try a 2mg klonopin that he filled in a
pharmacy in the US virgen island the brand was activia labs.and for my
surprice it work great the uder brans must have a coding to make the
mediction .And i never broke on hives all over my body.Ihave only medicare
from my social security and mass health insurace.And for my surprice not
many of the drug stores carry your product or the brand olso well tolerated
PUDEU.please i really need your help iam a afganistan veteran and not even
in there drug pharmacy carry this brand.Inot asking for handouts but i will
be very gratfull if your moltymillion dollar company can help a feloow
vet.iam at the precent time bying the brand klonopin with is very expensive
for 90pills i pay 195.45 very mounth it works becuase it the brand one .But
like i set later you brand workes as good as the brand .Will you be soind
ans sending me a cupond that i can fill in a pharmacy in CANADA OR A
sampele to inforce this type of generic medication that works like the
brand klonopin.I will be very greatfull and spred the word. my phone num is
area413 324-4010 or my cell phone 413-314-314-1963. thank you fore your
help SINCERLLY SARGENT MAJOR US MARINE CORPS
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