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Product trade name: PMS-Temazepam
Pharmaceutical active ingredients containing related brand and generic drugs, medications or other health care products: PMS-Temazepam available forms, composition, doses: PMS-Temazepam destination | category: Indications and usages, anatomical therapeutic chemical and diseases classification codes: Pharmaceutical companies, researchers, developers, manufacturers, distributors and suppliers: Online pharmacy, drugstores, pharma, health and beauty shops selling this or related pharmaceutical products: There is an additional general information about this medication active ingredient temazepam: Pharmacological action PMS-Temazepam is an anxiolytic drug (tranquilizer) from the group of benzodiazepines. This medication eliminates the state of tension, fear, anxiety, increased excitability, irritability. It increases the sensitivity of the GABA neurotransmitter receptor (GABA). Hypnotic and sedative effect is mainly due to the inhibition of cell activity of the reticular activating system of the brain. This drug is effective for short-term treatment of insomnia characterized by difficulty falling asleep, frequent nocturnal and / or early morning awakenings. May be effective in the prevention and treatment of insomnia associated with sudden changes in sleep patterns. PMS-Temazepam exhibits a moderate anticonvulsant, muscle relaxant (central) and antifobicheskoe action. Pharmacokinetics PMS-Temazepam is rapidly and almost completely absorbed from the gastrointestinal tract. Cmax achieved within 1-2 h and is 669-982 ng / ml. The plasma protein binding is 96%. This medicine penetrates through the BBB, placenta, into breast milk. Css is observed after 1-3 days of treatment. PMS-Temazepam metabolized in the liver through direct binding to glucuronic acid to form inactive metabolites. An excretion is carried out in two phases: T1/2 in the first phase is 0.4-0.6 h, the second one is 3.5 - 18.4 h. Kidneys excrete 80-90%, the rest - with the feces. A cumulation with re-appointment is minimal (applies to benzodiazepines with short and medium-sized T1/2). Why is PMS-Temazepam prescribed? Neurosis and psychopathy, accompanied by anxiety, fear, tension, depression, and hypochondriacal syndrome, neurasthenia, depression, involutional. Dosage and administration PMS-Temazepam is taken orally in 10 mg 3 times / day. If necessary, the dose may be increased to 20 mg 3 times / day. PMS-Temazepam side effects, adverse reactions CNS and peripheral nervous system: at the beginning of treatment (especially in elderly patients) - drowsiness, dizziness, fatigue, impaired concentration, ataxia, disorientation, unsteady gait and poor coordination of movements, weakness, numbing of emotions, mental retardation and motor responses; rarely - headache, euphoria, depression, tremor, depressed mood, numbness, impaired memory (including anterograde amnesia), confusion, dystonic extrapyramidal reactions (involuntary movements of the body, including eyes), fatigue, muscle weakness during the day, dysarthria, blurred speech; extremely rare - paradoxical reactions (aggressive outbursts, psychomotor agitation, fear, suicidal tendencies, muscle cramps, confusion, hallucinations, severe agitation, irritability, anxiety, insomnia). Cardiovascular system: reduction of blood pressure, rarely - tachycardia. Hematopoietic system: leukopenia, neutropenia, agranulocytosis (chills, pyrexia, sore throat, unusual tiredness or weakness), anemia, and thrombocytopenia. Digestive system: dry mouth or salivation, heartburn, nausea, vomiting, anorexia, constipation, diarrhea, abnormal liver function, elevated liver transaminases and alkaline phosphatase, jaundice. Urinary system: urinary incontinence, urinary retention, impaired renal function. Reproductive system: increased or decreased libido, dysmenorrhea. Allergic reactions: skin rash, itching. Other: addiction, drug dependency, rare - respiratory center depression, blurred vision (diplopia), bulimia, weight loss. With a sharp decrease in dose or stop taking: withdrawal symptoms (irritability, headache, anxiety, excitement, agitation, anxiety, nervousness, sleep disturbances, dysphoria, a spasm of smooth muscles of internal organs and skeletal muscles, depersonalization, increased sweating, depression, nausea, vomiting, tremor, disorders of perception, including hyperacusis, paresthesia, photophobia, tachycardia, convulsions, hallucinations, rare - acute psychosis). PMS-Temazepam contraindications Coma, shock, acute alcohol intoxication to the weakening of vital signs, acute intoxication of drugs have a depressing effect on the CNS (narcotics, sedatives and psychotropic drugs), myasthenia gravis, angle-closure glaucoma (acute onset or predisposition), severe COPD (degree of progression of respiratory failure), acute respiratory failure, severe depression (suicidal tendencies may be observed), pregnancy, lactation (breastfeeding), children and teens up to age 18 (safety and efficacy have not decided), increased sensitivity to temazepam. Using during pregnancy and breastfeeding PMS-Temazepam is contraindicated during pregnancy and lactation (breastfeeding). Effects on the fetus: teratogenicity (especially in the I trimester), CNS depression, respiratory failure and suppression of sucking reflex in infants whose mothers used temazepam. Special instructions With caution PMS-Temazepam should be used in patients with hepatic and / or renal failure, cerebral and spinal ataxia, hyperkinesis, drug addiction in history, a tendency to abuse of psychotropic drugs, organic brain disease, psychosis (possible paradoxical reactions), hypoproteinemia, sleep apnea (or perceived) in elderly patients. During the period of drug treatment should not drink alcohol. Patients receiving temazepam, you should refrain from activities in potentially hazardous activities that require attention and rapid psychomotor reactions. PMS-Temazepam drug interactions When this drug applied simultaneously with: - drugs that have a dampening effect on the central nervous system, it is possibly increased inhibitory effect on the CNS. - oral contraceptives the effectiveness of PMS-Temazepam is reduced. There was described a case of toxic action temazepam (drowsiness, confusion) while the use of disulfiram. PMS-Temazepam in case of emergency / overdose Symptoms: drowsiness, disorientation, slurred speech, depression of reflexes, coma, possible respiratory depression, hypotension. Treatment: induction of vomiting and the appointment of activated charcoal (if the patient is conscious), gastric lavage through a tube (if patient is unconscious), monitoring of vital functions, symptomatic treatment, IV introduction of liquids (for increased urine output). With the development of excitation it should not be used barbiturates. The specific antidote is flumazenil (benzodiazepine receptor antagonist).
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